10 Best Bed Bug Sprays 2025 in the United States

The Ortho Home Defense Max Bed Bug, Flea and Tick Killer is a versatile 1-gallon spray designed to tackle bed bugs, including their eggs, as well as fleas and ticks. One of its strong points is its effectiveness against even the toughest bed bugs, including those resistant to common treatments. The Comfort Wand that comes with it makes it easier to apply, especially in hard-to-reach places such as mattress seams and baseboards. This feature can be a significant advantage for those dealing with infestations in multiple areas of their home.

Safety-wise, it should be used with care, keeping in mind the advice to use it as a spot treatment. It’s also important to note that while it is effective, it forms only one part of a three-step treatment system recommended by Ortho, which may require additional purchases for the best results. Users have generally rated it positively, with a 4.4 out of 5-star rating from nearly 29,000 reviews, indicating a high level of customer satisfaction. However, some users might find the scent unpleasant as it is noted to have a tick scent.

In terms of convenience, the product’s large volume (1 gallon) means you’ll have plenty of spray to cover a significant area, but it also makes the container heavier and potentially more cumbersome to handle. This product is well-suited for those looking for a comprehensive, albeit multi-step, solution to bed bug and flea infestations in their home.

The Ortho Home Defense Max Bed Bug Killer is a spray designed to target tough bed bugs, including those resistant to common chemicals, and their eggs. It comes in an 18-ounce bottle and is sold in a convenient two-pack. This spray works well as a spot treatment around bed frames, headboards, floors, and carpets. One of its strong points is that it continues to kill bed bugs for up to 16 weeks on non-porous surfaces like ceramic, which helps maintain protection over time. Besides bed bugs, it also kills fleas, brown dog ticks, and other pests, making it a versatile option.

The spray is unscented, which is a plus if you prefer to avoid strong or unpleasant odors often found in pest control products. In terms of safety, while the product is effective, it is meant for targeted spots rather than widespread application, so careful use according to instructions is important. The spray is easy to apply and fits well for those who want a straightforward solution without complicated steps.

This product works best as part of a treatment plan, since it’s primarily for spot treatment and is recommended to be used alongside other products like traps and powders from the same range to fully eliminate bed bugs. If you’re looking for a spray that handles resistant bugs effectively, offers residual protection, and doesn’t have a strong smell, this is a solid choice. It is not an all-in-one solution and performs best when combined with other measures.

The BASF PT Alpine Flea & Bed Bug Killer is a ready-to-use aerosol spray designed for swift and effective pest control. It claims to offer quick results with a fast knockdown of bed bugs and fleas, making it a practical choice for those needing immediate relief. The spray is designed to be effective for up to three weeks, and it even targets hatching eggs for up to seven months, ensuring long-lasting control. This makes it an excellent option for maintaining an ongoing defense against infestations.

While it provides extensive coverage, it should not be applied to the entire mattress, only specific areas like edges, tufts, folds, sides, and seams, which might require some careful application to ensure thorough treatment. The active ingredient Dinotefuran is safe for public health use and in food handling environments, adding a layer of safety, but like all insecticides, it’s crucial to follow the label instructions meticulously. The quick-dry, non-staining formula ensures it won’t damage surfaces, which is a significant advantage for household use.

Users have rated it highly for being easy to apply and effective, although handling the aerosol can might be slightly challenging for some. Its versatility makes it suitable for various environments, including homes, hotels, and veterinary clinics. In terms of odor, most users report minimal to no lingering scent, which enhances user comfort. This spray ranks well in customer reviews and sales, indicating general satisfaction and reliability. However, state restrictions may apply, which could limit availability in certain areas.